解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:Stress responses provide valuable models for deciphering the transcriptional networks controlling the adaptation of the cell to its environment. We analyzed the transcriptome response of yeast to toxic concentrations of selenite. We used gene network mapping tools to identify functional pathways and transcri...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-9-333
更新日期:2008-07-15 00:00:00
abstract:BACKGROUND:Alu repetitive elements are the abundant sequences in human genome. Diversity of DNA sequences of these elements makes difficult the construction of theoretical patterns of Alu repeats cleavage by restriction endonucleases. We have proposed a method of restriction analysis of Alu repeats sequences in silico....
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-9-305
更新日期:2008-06-26 00:00:00
abstract:BACKGROUND:Short non-coding RNAs (ncRNAs) perform their cellular functions in ribonucleoprotein (RNP) complexes, which are also essential for maintaining the stability of the ncRNAs. Depletion of individual protein components of non-coding ribonucleoprotein (ncRNP) particles by RNA interference (RNAi) may therefore aff...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-9-278
更新日期:2008-06-11 00:00:00
abstract:BACKGROUND:The colonial cyanobacterium Microcystis proliferates in a wide range of freshwater ecosystems and is exposed to changing environmental factors during its life cycle. Microcystis blooms are often toxic, potentially fatal to animals and humans, and may cause environmental problems. There has been little invest...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-9-274
更新日期:2008-06-05 00:00:00
abstract:BACKGROUND:Natural contamination and anthropogenic pollution of soils are likely to be major determinants of functioning and survival of keystone invertebrate taxa. Soil animals will have both evolutionary adaptation and genetically programmed responses to these toxic chemicals, but mechanistic understanding of such is...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-9-266
更新日期:2008-06-03 00:00:00
abstract:BACKGROUND:Tumor angiogenesis is a highly regulated process involving intercellular communication as well as the interactions of multiple downstream signal transduction pathways. Disrupting one or even a few angiogenesis pathways is often insufficient to achieve sustained therapeutic benefits due to the complexity of a...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-9-264
更新日期:2008-06-02 00:00:00
abstract:BACKGROUND:Selenium (Se) is a trace element that occurs in proteins in the form of selenocysteine (Sec) and in tRNAs in the form of selenouridine (SeU). Selenophosphate synthetase (SelD) is required for both utilization traits. However, previous research also revealed SelDs in two organisms lacking Sec and SeU, suggest...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-9-251
更新日期:2008-05-29 00:00:00
abstract:BACKGROUND:Retrogenes are processed copies of other genes. This duplication mechanism produces a copy of the parental gene that should not contain introns, and usually does not contain cis-regulatory regions. Here, we computationally address the evolutionary origin of promoter and other cis-regulatory regions in retrog...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-9-241
更新日期:2008-05-22 00:00:00
abstract:BACKGROUND:Leishmania (L) are intracellular protozoan parasites that are able to survive and replicate within the harsh and potentially hostile phagolysosomal environment of mammalian mononuclear phagocytes. A complex interplay then takes place between the macrophage (MPhi) striving to eliminate the pathogen and the pa...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-9-238
更新日期:2008-05-21 00:00:00
abstract:BACKGROUND:Studying mitochondrial (mt) genomics has important implications for various fundamental areas, including mt biochemistry, physiology and molecular biology. In addition, mt genome sequences have provided useful markers for investigating population genetic structures, systematics and phylogenetics of organisms...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-9-224
更新日期:2008-05-16 00:00:00
abstract:BACKGROUND:Transposable elements are selfish genetic sequences which only occasionally provide useful functions to their host species. In addition, models of mobile element evolution assume a second type of selfishness: elements of different families do not cooperate, but they independently fight for their survival in ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-9-219
更新日期:2008-05-14 00:00:00
abstract:BACKGROUND:The superior temporal gyrus (STG), which encompasses the primary auditory cortex, is believed to be a major anatomical substrate for speech, language and communication. The STG connects to the limbic system (hippocampus and amygdala), the thalamus and neocortical association areas in the prefrontal cortex, a...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-9-199
更新日期:2008-04-29 00:00:00
abstract:BACKGROUND:Affymetrix GeneChip typically contains multiple probe sets per gene, defined as sibling probe sets in this study. These probe sets may or may not behave similar across treatments. The most appropriate way of consolidating sibling probe sets suitable for analysis is an open problem. We propose the Analysis of...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-9-188
更新日期:2008-04-24 00:00:00
abstract:BACKGROUND:Infectious salmon anemia virus (ISAV) causes a multisystemic disease responsible for severe losses in salmon aquaculture. Better understanding of factors that explain variations in resistance between individuals and families is essential for development of strategies for disease control. To approach this, we...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-9-179
更新日期:2008-04-18 00:00:00
abstract:BACKGROUND:Housekeeping (HK) genes are ubiquitously expressed in all tissue/cell types and constitute a basal transcriptome for the maintenance of basic cellular functions. Partitioning transcriptomes into HK and tissue-specific (TS) genes relatively is fundamental for studying gene expression and cellular differentiat...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-9-172
更新日期:2008-04-16 00:00:00
abstract:BACKGROUND:Gene expression profiling is a promising approach to better estimate patient prognosis; however, there are still unresolved problems, including little overlap among similarly developed gene sets and poor performance of a developed gene set in other datasets. RESULTS:We applied a gene sets approach to develo...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-9-177
更新日期:2008-04-16 00:00:00
abstract:BACKGROUND:Increasing evidence suggests that overlapping genes are much more common in eukaryotic genomes than previously thought. In this study we identified and characterized the overlapping genes in a set of 13,484 pairs of human-mouse orthologous genes. RESULTS:About 10% of the genes under study are overlapping ge...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-9-169
更新日期:2008-04-14 00:00:00
abstract:BACKGROUND:Duplication, followed by fixation or random loss of novel genes, contributes to genome evolution. Particular outcomes of duplication events are possibly associated with pathogenic life histories in fungi. To date, differential gene gain and loss have not been studied at genomic scales in fungal pathogens, de...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-9-147
更新日期:2008-03-28 00:00:00
abstract:BACKGROUND:The response of the trout, O. mykiss, head kidney to bacterial lipopolysaccharide (LPS) or active and attenuated infectious hematopoietic necrosis virus (IHNV and attINHV respectively) intraperitoneal challenge, 24 and 72 hours post-injection, was investigated using a salmonid-specific cDNA microarray. RESU...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-9-141
更新日期:2008-03-26 00:00:00
abstract:BACKGROUND:Arsenic is a carcinogen that is known to induce cell transformation and tumor formation. Although studies have been performed to examine the modulation of signaling molecules caused by arsenic exposure, the molecular mechanisms by which arsenic causes cancer are still unclear. We hypothesized that arsenic al...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-9-115
更新日期:2008-03-03 00:00:00
abstract:BACKGROUND:Cowpea, Vigna unguiculata (L.) Walp., is one of the most important food and forage legumes in the semi-arid tropics because of its drought tolerance and ability to grow on poor quality soils. Approximately 80% of cowpea production takes place in the dry savannahs of tropical West and Central Africa, mostly b...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-9-103
更新日期:2008-02-27 00:00:00
abstract:BACKGROUND:Diversity in rates of gene expression is essential for basic cell functions and is controlled by a variety of intricate mechanisms. Revealing general mechanisms that control gene expression is important for understanding normal and pathological cell functions and for improving the design of expression system...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-9-92
更新日期:2008-02-25 00:00:00
abstract:BACKGROUND:With the sequence of the Plasmodium falciparum genome and several global mRNA and protein life cycle expression profiling projects now completed, elucidating the underlying networks of transcriptional control important for the progression of the parasite life cycle is highly pertinent to the development of n...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-9-70
更新日期:2008-02-07 00:00:00
abstract:BACKGROUND:Musa species (Zingiberaceae, Zingiberales) including bananas and plantains are collectively the fourth most important crop in developing countries. Knowledge concerning Musa genome structure and the origin of distinct cultivars has greatly increased over the last few years. Until now, however, no large-scale...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-9-58
更新日期:2008-01-30 00:00:00
abstract:BACKGROUND:The genus Populus includes poplars, aspens and cottonwoods, which will be collectively referred to as poplars hereafter unless otherwise specified. Poplars are the dominant tree species in many forest ecosystems in the Northern Hemisphere and are of substantial economic value in plantation forestry. Poplar h...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-9-57
更新日期:2008-01-29 00:00:00
abstract:BACKGROUND:Little is known about the genome sequences of Euphausiacea (krill) although these crustaceans are abundant components of the pelagic ecosystems in all oceans and used for aquaculture and pharmaceutical industry. This study reports the results of an expressed sequence tag (EST) sequencing project from differe...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-9-45
更新日期:2008-01-28 00:00:00
abstract:BACKGROUND:Microsatellites are highly abundant in eukaryotic genomes but their function and evolution are not yet well understood. Their elevated mutation rate makes them ideal markers of genetic difference, but high levels of unexplained heterogeneity in mutation rates among microsatellites at different genomic locati...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-9-49
更新日期:2008-01-28 00:00:00
abstract:BACKGROUND:Mobile genetic elements (MGEs) play an essential role in genome rearrangement and evolution, and are widely used as an important genetic tool. RESULTS:In this article, we present genetic maps of recently active Insertion Sequence (IS) elements, the simplest form of MGEs, for all sequenced cyanobacteria and ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-9-36
更新日期:2008-01-24 00:00:00
abstract:BACKGROUND:Controlling gene expression is fundamental to biological complexity. The nematode Caenorhabditis elegans is an important model for studying principles of gene regulation in multi-cellular organisms. A comprehensive parts list of putative regulatory motifs was yet missing for this model system. In this study,...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-9-30
更新日期:2008-01-23 00:00:00
abstract:BACKGROUND:The sequential nature of gel-based marker systems entails low throughput and high costs per assay. Commonly used marker systems such as SSR and SNP are also dependent on sequence information. These limitations result in high cost per data point and significantly limit the capacity of breeding programs to obt...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-9-26
更新日期:2008-01-22 00:00:00
abstract:BACKGROUND:Repeat masking is an important step in the EST analysis pipeline. For new species, genomic knowledge is scarce and good repeat libraries are typically unavailable. In these cases it is common practice to mask against known repeats from other species (i.e., model organisms). There are few studies that investi...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-9-23
更新日期:2008-01-18 00:00:00
abstract:BACKGROUND:On a single strand of genomic DNA the number of As is usually about equal to the number of Ts (and similarly for Gs and Cs), but deviations have been noted for transcribed regions and origins of replication. RESULTS:The mouse genome is shown to have a segmented structure defined by strand bias. Transcriptio...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-9-16
更新日期:2008-01-14 00:00:00
abstract:BACKGROUND:While changes in chromosome number that result in aneuploidy are associated with phenotypic consequences such as Down syndrome and cancer, the molecular causes of specific phenotypes and genome-wide expression changes that occur in aneuploids are still being elucidated. RESULTS:We employed a segmental aneup...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-9-7
更新日期:2008-01-10 00:00:00
abstract:BACKGROUND:Iron homeostasis is a key metabolism for most organisms. In many bacterial species, coordinate regulation of iron homeostasis depends on the protein product of a Fur gene. Fur also plays roles in virulence, acid tolerance, redox-stress responses, flagella chemotaxis and metabolic pathways. RESULTS:We conduc...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-9-S1-S11
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:The ability to rapidly map millions of oligonucleotide fragments to a reference genome is crucial to many high throughput genomic technologies. RESULTS:We propose an intuitive and efficient algorithm, titled extreme MApping of OligoNucleotide (xMAN), to rapidly map millions of oligonucleotide fragments to a...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-9-S1-S20
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:An important subfamily of membrane proteins are the transmembrane alpha-helical proteins, in which the membrane-spanning regions are made up of alpha-helices. Given the obvious biological and medical significance of these proteins, it is of tremendous practical importance to identify the location of transmem...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-9-S1-S7
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Small untranslated RNAs (sRNAs) seem to be far more abundant than previously believed. The number of sRNAs confirmed in E. coli through various approaches is above 70, with several hundred more sRNA candidate genes under biological validation. Although the total number of sRNAs in any one species is still un...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-8-467
更新日期:2007-12-19 00:00:00
abstract:BACKGROUND:Armigeres subalbatus is a natural vector of the filarial worm Brugia pahangi, but it rapidly and proficiently kills Brugia malayi microfilariae by melanotic encapsulation. Because B. malayi and B. pahangi are morphologically and biologically similar, the Armigeres-Brugia system serves as a valuable model for...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-8-463
更新日期:2007-12-18 00:00:00
abstract:BACKGROUND:Matrix attachment regions (MAR) are the sites on genomic DNA that interact with the nuclear matrix. There is increasing evidence for the involvement of MAR in regulation of gene expression. The unsuitability of experimental detection of MAR for genome-wide analyses has led to the development of computational...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-8-418
更新日期:2007-11-15 00:00:00
abstract:BACKGROUND:Transposable elements constitute a significant fraction of plant genomes. The PIF/Harbinger superfamily includes DNA transposons (class II elements) carrying terminal inverted repeats and producing a 3 bp target site duplication upon insertion. The presence of an ORF coding for the DDE/DDD transposase, requi...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-8-409
更新日期:2007-11-09 00:00:00